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British Medical Bulletin 32:100 (1976)
© 1976 The British Council

addendum

ADDENDUM

S. Dorsch and B. Roser

Abstract

Data have just been published by S. Dorsch & B. Roser (Nature (London) 1975, 258, 233–235) showing that thoracic duct lymphocyte populations obtained from neonatally injected tolerant rats, and consisting of almost pure T cells, transferred specific tolerance to skin allografts when injected into sublethally irradiated syngeneic recipients. Their data, which they believe to exclude the participation of F1 hybrid cells stemming from the tolerance-inducing inoculum, are convincing—except that the criteria of tolerance applied (survival of skin allografts "for at last 50 days") do not guarantee that the cell donors had been fully tolerant.


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