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British Medical Bulletin 41:251-256 (1985)
© 1985 The British Council

research-article

INTER-TISSUE NITROGEN FLUXES

Patricia Lund and Dermot H Williamson

Metabolic Research Laboratory Nuffield Department of Clinical Medicine Radcliffe Infirmary Oxford

Abstract

In normal man there is continual extraction and release of amino acids by tissues, the extent of which varies with the physiological state (absorptive, postabsorptive, composition of diet etc.) and the particular tissue. This inter-tissue flux of amino acids has two main roles, the supply of precursors for protein synthesis and transport of carbon and nitrogen for specific functions in individual tissues (e.g. gluconeogenesis in the liver, excretion of ammonia by the kidney). Trauma is accompanied by increased excretion of nitrogen, the magnitude of the loss being directly related to the severity of the injury. The source of the nitrogen is mainly the proteins of skeletal muscle. It now appears that the multiplicity of the hormonal changes after trauma, and in particular the synergistic effects, are responsible for the increased efflux of amino acids from skeletal muscle.


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