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British Medical Bulletin 41:265-273 (1985)
© 1985 The British Council

research-article

LIVER EXPORT PROTEINS AND TRAUMA

A Fleck, C M Colley and M A Myers

Department of Chemical Pathology Charing Cross and Westminster Medical School London

Abstract

The effects of trauma on the plasma proteins of liver origin have been summarized, and possible mechanisms reviewed. The prompt fall in the concentration of these proteins, including the acute-phase proteins, results from a rapid increase in the loss of protein to the tissue spaces following an increase in microvascular permeability. This increased permeability probably lasts for several days and accounts for the continuation of the depressed albumin and transferin levels, which is unlikely to be due to either nutritional or endocrine changes. The contrasting increase in the concentration of the acutephase plasma proteins after a short lag is brought about by a mediator, interleukin 1, produced by macrophages in response to various products of tissue damagae.


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