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British Medical Bulletin 41:274-280 (1985)
© 1985 The British Council

research-article

HAEMOSTATIC RESPONSE TO TRAUMA

Bruce Bennett and Hamish M A Towler

Department of Medicine, University of Aberdeen

Abstract

Normal haemostasis after trauma involves vasoconstriction, platelet adhesion and aggregation to form a platelet plug, fibrin formation, and fibrinolytic processes which ultimately remove deposited fibrin. Sealing of small wounds consumes too little in terms of platelets and clotting factors for the changes in their circulating concentrations to be detectable. Evidence that the processes are occuring depends on the detection of by-products of the reactions not normally present in large amouts in the blood. Stress produces transiently a restricted range of changes in the haemostatic mechanism. Trauma is followed by a sustained change which might be regarded as favouring haemostatic security. Normally, haemostatic reactions are restricted to the site of trauma. Rarely, the processes are inappropriately disseminated and fibrin forms remote from the injury causing tissue damage, exhausting the haemostatic mechanisms and resulting in a severe bleeding syndrome.


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[Abstract] [PDF]


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