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British Medical Bulletin 41:351-356 (1985)
© 1985 The British Council

research-article

VIRAL KERATITIS

James McGill and G M Scott

Southampton Eye Hospital
Department of Clinical Microbiology University College Hospital London

Abstract

Of the viruses which commonly cause superficial eye disease, only herpes simplex and varicella zoster appear amenable to specific treatment at present. Superficial herpetic corneal ulcers respond well to a number of nucleoside and nucleotide derivatives applied tropically, and this is an excellent clinical model in which to test new agents in controlled trials. In such studies, combinations of alpha-interferons with acyclovir or trifluorothymidine have been shown to be more effective than either alone. No strategy has been found to affect recurrences of herpes simplex keratitis. Furthermore, deep stromol disease, uveitis and infections following corneal transplants are more difficult to treat because persistent inflammation does not necessarily reflect persistent viral replication, and may be aggravated by drug toxicity. Controlled trials in herpes zoster ophthalmicus have recently shown that there is a definite advantage in using antiviral agents over steroids.


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This article has been cited by other articles:


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P. P. Sarangi, B. Kim, E. Kurt-Jones, and B. T. Rouse
Innate Recognition Network Driving Herpes Simplex Virus-Induced Corneal Immunopathology: Role of the Toll Pathway in Early Inflammatory Events in Stromal Keratitis
J. Virol., October 15, 2007; 81(20): 11128 - 11138.
[Abstract] [Full Text] [PDF]


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