Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (71)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Quinn, N. P
Right arrow Articles by Marsden, C D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Quinn, N. P
Right arrow Articles by Marsden, C D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 42:86-90 (1986)
© 1986 The British Council

research-article

DEMENTIA AND PARKINSON'S DISEASE — PATHHOLOGICAL AND NEUROCHEMICAL CONSIDERATIONS

Niall P Quinn, Martin N Rossor and C David Marsden

University Department of Neurology, Institute of Psychiatry and King's College School of Medicine London

Abstract

The prevalence of dementia in Parkinson's disease is greater than that expected in an age-matched population. While the pathology of Parkinson's disease itself may cause cognitive deficits, this seems unlikely to be responsible for the excess prevalence of dementia. Coincidental Alzheimer's disease certainly occurs, but again does not appear to account for the excess of dementia. However, coincident subclinical degrees of Alzheimer change may combine with similar biochemical and neuronal loss due to Parkinson's disease to cause a deficit sufficient to lead to dementia. Such superimposition of the pathological and biochemical changes of the two diseases could account for a wide spectrum of clinical presentations of the "parkingsonian dement" or the "demented parkinsonian".


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Learn. Mem.Home page
C. Exner, J. Koschack, and E. Irle
The Differential Role of Premotor Frontal Cortex and Basal Ganglia in Motor Sequence Learning: Evidence From Focal Basal Ganglia Lesions
Learn. Mem., November 1, 2002; 9(6): 376 - 386.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
H. I. Hurtig, J. Q. Trojanowski, J. Galvin, D. Ewbank, M. L. Schmidt, V. M.- Y. Lee, C. M. Clark, G. Glosser, M. B. Stern, S. M. Gollomp, et al.
Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease
Neurology, May 23, 2000; 54(10): 1916 - 1921.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
O. L. Lopez, I. Litvan, K. E. Catt, R. Stowe, W. Klunk, D. I. Kaufer, J. T. Becker, and S. T. DeKosky
Accuracy of four clinical diagnostic criteria for the diagnosis of neurodegenerative dementias
Neurology, October 1, 1999; 53(6): 1292 - 1292.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
N. Quinn
Fortnightly Review: Parkinsonism--recognition and differential diagnosis
BMJ, February 18, 1995; 310(6977): 447 - 452.
[Abstract] [Full Text]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.