Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Hansen, J. A
Right arrow Articles by Thomas, E D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hansen, J. A
Right arrow Articles by Thomas, E D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 43:203-216 (1987)
© 1987 The British Council

research-article

Transplantation of hematopoietic stem cells (HSC)

John A Hansen, Patrick G Beatty, Claudio Anasetti, Paul J Martin, Eric Mickelson and E Donnall Thomas

Fred Hutchinson Cancer Research Centre, Pugeof Sound Blood Centre, and the Department of Medicine, University of Washington Seattle, Washington, USA

Abstract

HLA compatibility is a significant factor in clinical allogeneic marrow transplantation. Disparity for HLA determinants, either class I A locus or B locus products, or class II ‘Dw’ clusters, increases the rate of onset and overall incidence of clinically significant GVHD, and also increases the incidence of graft failure. The risk of graft failure and GVHD are proportional to the degree of HLA disparity. From the data available, there is a trend for class I HLA-A or B locus disparity to cause more GVHD than disparity for class II HLA-‘Dw’ determinants. This apparent difference, however, is not significant. Although an increasing number of allogeneic marrow transplants from HLA identical unrelated volunteer donors are being performed, the risk of graft rejection and significant GVHD are not known. There have been successful transplants from unrelated donors; however, the GVHD observed appears to be relatively active. A major issue, to be resolved before the identification of unrelated volunteer donors can be feasible and the outcome of unrelated donor transplants is reasonably successful, concerns the question of what the minimal requirements for unrelated donor/recipient HLA compatibility will be.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.