Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Owen, D A A
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Owen, D A A
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 43:256-269 (1987)
© 1987 The British Council

research-article

Inflammation—histamine and 5-hydroxytryptamine

D A A Owen

Department of Pharmacology, Smith Kline & French Research Limited Hertfordshire

Abstract

This chapter has considered the role of histamine and 5-hydroxytryptamine in acute inflammation. 5-hydroxytryptamine has an important role in rodents but can be excluded from a major role in non rodent species. In contrast, histamine is clearly important in acute inflammation associated with mast cell degranulation in non rodent species including man. This role of histamine has led to important clinical use of histamine antagonists to suppress inflammatory responses such as allergic rhinitis, various urticarias and asthma. There is little evidence to support an important role for either amine in chronic inflammation.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.