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British Medical Bulletin 43:386-400 (1987)
© 1987 The British Council

research-article

Peptides and neurogenic inflammation

John C Foreman

Department of Pharmacology, University College London London

Abstract

The evidence for the involvement of the sensory nervous system in generating some of the manifestations of inflammation is compelling. Polymodal nociceptor activation generates axon-reflexes in the terminal arborisations of primary afferent neurones. These reflexes cause the C fibres to release neuropeptides which initiate inflammatory changes. The nature of the neuropeptide involved is uncertain but substance P is the strongest candidate. Neurokinin A and calcitonin gene-related peptide are other possible candidates. These neuropeptides can exert direct effects on vascular smooth muscle and endothelium to increase flow and permeability. The evidence that histamine released from mast cells by neuropeptides may also participate in neurogenic inflammation is presented.


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