Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Hopwood, D A
Right arrow Articles by Lamb, F I
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hopwood, D A
Right arrow Articles by Lamb, F I
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 44:528-546 (1988)
© 1988 The British Council

research-article

Molecular biology of mycobacteria

D A Hopwood, T Kieser, M J Colston and F I Lamb

John Innes Institute and AFRC Institute of Plant Science Research Norwich
National Institute for Medical Research London

Abstract

The application of molecular biology to the understanding of mycobacterial infections has recently begun. Basic information such as the size and G+C content of the Mycobacterium leprae and Mycobacterium tuberculosis genomes has been obtained, and the DNA has been cloned in Escherichia coli. Expression of mycobacterial genes, especially those coding for immunologically active proteins has been achieved. The use of Streptomyces as a cloning host for mycobacterial DNA is being explored and attempts are being made to develop cloning systems involving cultivable mycobacteria. It is anticipated that the study of the molecular biology of the mycobacteria will lead to important developments in the diagnosis of mycobacterial infections, the cloning of enzyme targets for drugs and of immunologically important molecules, the understanding of pathogenicity, and the development of recombinant vaccines.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.