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British Medical Bulletin 44:624-634 (1988)
© 1988 The British Council

research-article

Macrophage antimycobacterial mechanisms

D B Lowrie and P W Andrew

MRC Tuberculosis and Related Infections Unit, Postgraduate Medical School London
Department of Microbiology, Leicester University Leicester

Abstract

Hydrogen peroxide-dependent and lysosomal mechanisms can operate against mycobacteria in macrophages. The relative importance of these mechanisms against the different mycobacteria is still unclear with recent studies lending little further support to earlier evidence for peroxide-mediated killing. Impairment of lysosome function, through inhibition of fusion or escape into the cytoplasm, is an established phenomenon but we still can only guess at its significance. Intracellular bacteriostasis is a frequent manifestation of immunological activation of macrophages but the mechanisms and significance of this too are unclear.


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