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British Medical Bulletin 44:650-664 (1988)
© 1988 The British Council

research-article

Animal models in leprosy

R J W Rees

Department of Communicable Diseases, Clinical Research Centre Harrow, Middlesex

Abstract

Although the leprosy becillus was the first of the family of mycobacteria to be shown to cause disease in man, Mycobacterium leprae remains the only known bacterium causing disease in man that has not been cultured in vitro. Furthermore, it was only in 1960 that even an animal model became available, with the local and limited growth of M. leprae in the mouse following footpad inoculation. Over the past 27 years this mouse footpad animal model, with the nine-banded armadillo animal model since 1971, have been successfully exploited, providing for the first time the opportunity for studying in detail the bacteriology, chemotherapy, immunology and pathogenesis of leprosy in laboratories throughout the world. The unique contributions these animal models have already made to advances in the field of leprosy research, as well as the future prospects from the use of primate animal models, are reviewed in this chapter.


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