Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (55)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Tooke, J E
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tooke, J E
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 45:206-223 (1989)
© 1989 The British Council

research-article

Microcirculation and diabetes

J E Tooke

Postgraduate Medical School, University of Exeter Exeter

Abstract

Many late complications of diabetes stem from damage to the microcirculation Changes in the microvascular wall, haemodynamic control and circulating blood may all contribute to impairment of capillary transfer function although the relative importance of the various possible mechanisms is unclear. Early functional disturbance appears more responsive to optimal diabetic control than established disease, and as microangiopathy becomes clinically apparent organ tissue damage is compounded by secondary mechanisms. Until more is learnt of the biochemical and cellular basis of the component pathogenetic mechanisms optimal diabetic control early in the disease remains the sole available primary prevention strategy, although evidence is emerging that manipulation of microvascular haemodynamics may have therapeutic potential.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Diabetes Spectr.Home page
B. B. Dokken
The Pathophysiology of Cardiovascular Disease and Diabetes: Beyond Blood Pressure and Lipids
Diabetes Spectr, July 1, 2008; 21(3): 160 - 165.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
D. G. Armstrong and H. C. Nguyen
Improvement in Healing With Aggressive Edema Reduction After Debridement of Foot Infection in Persons With Diabetes
Arch Surg, December 1, 2000; 135(12): 1405 - 1409.
[Abstract] [Full Text] [PDF]

Home page
 ANGIOLOGYHome page
G. Yosipovitch, J. Schneiderman, D. J. van Dyk, A. Chetrit, G. Milo, and G. Boner
Impairment of the Postural Venoarteriolar Response in Young Type 1 Diabetic Patients: A Study by Laser Doppler Flowmetry
Angiology, July 1, 1996; 47(7): 687 - 691.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.