Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (22)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Derewenda, U
Right arrow Articles by Korber, F
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Derewenda, U
Right arrow Articles by Korber, F
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 45:4-18 (1989)
© 1989 The British Council

research-article

Molecular Structure of insulin: The insulin monomer and its assembly

U Derewenda, Z Derewenda, G G Dodson, R E Hubbard and F Korber

Department of Chemistry,University of York York, UK

Abstract

The insulin molecule contains 51 amino acids; it is made up of two peptide chains linked by disulphide bonds. Although it is active as a monomer, during its biosynthesis and storage it assembles to dimers and in the presence of zinc, to hexamers. X-ray analysis has revealed the 3-dimensional structure of the insulin molecule in its hexameric, dimeric and monomeric states. Two main conformations of insulin which differ in the extent of helix in the B chain (B9–B20 and B1–B20, respectively) have been identified. Other variations are seen in insulin when dimeric or monomeric. Reagenmts such as chloride and phenol govern the conformations present in the insulin hexamers and this can influence the behaviour and properties of insulin preparations employing them.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Histochem. Cytochem.Home page
G. Danscher and M. Stoltenberg
Zinc-specific Autometallographic In Vivo Selenium Methods: Tracing of Zinc-enriched (ZEN) Terminals, ZEN Pathways, and Pools of Zinc Ions in a Multitude of Other ZEN Cells
J. Histochem. Cytochem., February 1, 2005; 53(2): 141 - 153.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
A. B. Chausmer
Zinc, Insulin and Diabetes
J. Am. Coll. Nutr., April 1, 1998; 17(2): 109 - 115.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. S. Baldwin, F. Hollande, Z. Yang, Y. Karelina, A. Paterson, R. Strang, D. Fourmy, G. Neumann, and A. Shulkes
Biologically Active Recombinant Human Progastrin6-80 Contains a Tightly Bound Calcium Ion
J. Biol. Chem., March 9, 2001; 276(11): 7791 - 7796.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.