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British Medical Bulletin 45:425-437 (1989)
© 1989 The British Council

research-article

Transforming growth factors ß

J Justin Hsuan

Ludwig Institute for Cancer Research (Middlesex Hospital and University College Branch) London

Abstract

Since its discovery as a factor able to induce phenotypic transformation with tranforming growth factor {alpha} transforming growth factor ß (TGFß) has been found to have unexpectedly widespread and frequently, seemingly paradoxical effects on a variety of cell types. Thus, a significant property of TGFß activity is the ability to inhibit cellular growth and transformation. More recently, further important potential roles have also been found for TGFß including the control of embryonal development, cellular differentiation, hormone secretion and immune function. Multiple forms of both TGFß and TGFß receptors are now known to exist, which may generate a complex and diverse range of interacting signals The multifunctional actions of the TGFß family are frequently defined in concert with other extracellular factors and much still has to be understood concerning these synergistic processes.


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