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British Medical Bulletin 45:438-452 (1989)
© 1989 The British Council

research-article

Fibroblast growth factors

Andrew Baird1 and Patricia A Walicke2

1Laboratories for Neuroendocrinology, Salk Institute La Jolla, California, USA
2Department of Neuroscience, University of California at San Diego La Jolla, California, USA

Abstract

The existence of fibroblast growth factors (FGFs) was proposed over 40 years ago to account for the ability of tissue extracts to stimulate fibroblast proliferation In the 1970s it became clear that preparations containing FGF activity were in fact pleiotropic, affecting the growth and function of a wide variety of mesenchymal, endocrine and neural cells. Their angiogenic effects have promoted research in cardiology and neurology because of their proposed role in stimulating collateral vascularisation and recovery from ischemia. Their identity with a component of tumour angiogenesis factor activity has stimulated research in oncology and their capacity to enhance wound healing, nerve regeneration and cartilage repair has affected research in neurology, orthopaedic medicine and pathology. The potential therapeutic value of FGFs is just beginning to be realized and will be dependent on a concerted effort to establish their function in the regulation of normal cell homeostais and the pathophysiology of disease.


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