Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Heldin, C.-H.
Right arrow Articles by Westermark, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Heldin, C.-H.
Right arrow Articles by Westermark, B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 45:453-464 (1989)
© 1989 The British Council

research-article

Platelet-derived growth factors: A family of isoforms that bind to two disticnt receptors

Carl-Henrik Heldin and Bengt Westermark

Ludwig Institute for Cancer Research, Biomedical Center Uppsala, Sweden
Department of Pathology, University Hospital Uppsala, Sweden

Abstract

Platelet-derived growth factor (PDGF) is a mitogen for connective tissue cells and accurs as disulphide-bonded homodimers or heterodimers of related polypeptide chains. Recent date indicate that the isoforms have different functional activities due to the fact that they bind with different affinities to two distinct receptor types. The frequent expression of PDGF and PDGF receptors in normal as well as transformed cells, suggests roles for PDGF in autocrine and paracrine stimulation of cell growth in vivo


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
L. M. Strawn, F. Kabbinavar, D. P. Schwartz, E. Mann, L. K. Shawver, D. J. Slamon, and J. M. Cherrington
Effects of SU101 in Combination with Cytotoxic Agents on the Growth of Subcutaneous Tumor Xenografts
Clin. Cancer Res., July 1, 2000; 6(7): 2931 - 2940.
[Abstract] [Full Text]

Home page
 J. Cell Sci.Home page
M Shah, D. Foreman, and M. Ferguson
Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring
J. Cell Sci., January 3, 1995; 108(3): 985 - 1002.
[Abstract] [PDF]

Home page
 ScienceHome page
S. Aaronson
Growth factors and cancer
Science, November 22, 1991; 254(5035): 1146 - 1153.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.