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British Medical Bulletin 45:529-540 (1989)
© 1989 The British Council

research-article

Early gene induction by growh factors

J R Woodgett

Ludwig Institute for Cancer Research London, UK

Abstract

The mechanisms by which growth factors elicit their cellular effects include the rapid transcriptional activation of a set of genes. In the past five years much has been learned of the number, identity and even function of these genetic messengers and has begun to provide a molecular basis for certain growth factor responses. The identification and characterisation of the nuclear transcription factors that stimulate expression of these genes has established the involvement of several nuclear oncogenes underscoring the improvement of several nuclear oncogenes underscoring the importance of subversion of normal signal transduction pathways in neoplasia. Some of the immediate early genes themselves are trans-activators, participating in a cascade of gene indiuction. The current pace of progress should, in the next few years, bridge the remaining gap between the growth factor receptors and the nuclear transcription factors.


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