Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (52)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Woodhouse, K W
Right arrow Articles by James, O F W
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Woodhouse, K W
Right arrow Articles by James, O F W
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 46:22-35 (1990)
© 1990 The British Council

research-article

Hepatic drug metabolism and ageing

K W Woodhouse and O F W James

Geriatric Pharmacology Research Group, Department of Medicine (Geriatrics) and Clinical Pharmacology, The University of Newcastle Upon Tyne UK

Abstract

The hepatic clearance of many drugs is reduced in the elderly Contrary to previously held views we suggest the following:

  1. Specific activities of several cytochrome P-450 Phase I enzymes are not reduced with age per se in primate and man, nor is enzyme affinity for substrate changed.
  2. An important contribution to the reduced hepatic elimination is made by reduction in liver size and blood flow with advancing age.
  3. Major changes in liver drug metabolism may occur in frail old people. Future studies of hepatic drug metabolism and ageing must closely define the subject groups under study.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.