Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Anderson, T J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Anderson, T J
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 47:305-318 (1991)
© 1991 The British Council

research-article

Genesis and source of breast cancer

T J Anderson

Department of Pathology, University of Edinburgh Edinburgh, UK

Abstract

Premalignancy and cancer risk as indices of cancer origin have become less confusing. Firstly, we are now aware of the time scale of events leading up to clinical presentation, and secondly the nature of probability, inherent to a biological system influenced by genetics, the environment and hormones, is more widely appreciated. Improved understanding of the early phases of cancer, especially origins and sources, stems from correlation of epidemiological, endocrine and histological information. Such data specifically address the modulating influences on structure and activity of breast epithelial units by factors that are linked to cancer risk. Morphology of the normal breast remains a corner stone on which to build concepts of the cellular events involved in the genesis of cancer. Another line of evidence derives from well defined histological characteristics of pathological processes that have been reliably associated with increased cancer risk. These two aspects of analysis encourage belief that heterogeneity is a characteristic of this disease, which has more than one mode of origin and follows variable courses of aggression. In consequence, the aims behind programmes of breast cancer detection and prevention can become more realistic.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.