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British Medical Bulletin 47:690-702 (1991)
© 1991 The British Council

research-article

Mechanisms of the analgesic actions of opiates and opioids

A H Dickenson

Department of Pharmacology, University College London, UK

Abstract

It is now clear that there are three sub-types of the opiate receptor, mu, delta and kappa. Evidence for differential roles of those sub-types in pain modulation is accumulating since the advent of relatively selective agonists and more recently, antagonists for the three receptors. The actions of opioids in the spinal cord is reasonably well understood and there is increasing knowledge of supraspinal sites of action, peripheral analgesic effects in inflammatory states and in the interactions between opioid and non-opioid systems at spinal levels, which may strat to explain some of the clinical states with altered opioid sensitivity.


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