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British Medical Bulletin 49:642-652 (1993)
© 1993 The British Council
research-article |
Diabetes mellitus and free radicals
Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University College London London, UK
Abstract
Diabetes mellitus is a syndrome initially characterized by a loss of glucose homeostasis. The disease is progressive and is associated with high risk of atherosclerosis, kidney and nerve damage as well as blindness. Abnormalities in the regulation of peroxide and transition metal metabolism are postulated to result in establishment of the disease as well as its longer term complications. Diabetes mellitus is associated with oxidative reactions, particularly those which are catalyzed by decompartmentalized transition metals, but their causative significance in diabetic tissue damage remains to be established.
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