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British Medical Bulletin 49:873-912 (1993)
© 1993 The British Council

research-article

Transgenetics and cell biology of prion diseases: investigations of PrPSc synthesis and diversity

S B Prusiner

Departments of Neurology and Biochemistry and Biophysics, University of California San Francisco, California, USA

Abstract

Studies with Tg mice have contributed a wealth of new knowledge about the synthesis of prion particles and the pathogenesis of both the genetic and infectious forms of the prion diseases. Transgenetic studies argue persuasively that the ‘species barrier’ is due to differences in PrP gene sequences among mammals.


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