Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (94)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Mapp, P I
Right arrow Articles by Blake, D R
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mapp, P I
Right arrow Articles by Blake, D R
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 51:419-436 (1995)
© 1995 The British Council

research-article

Hypoxia, oxidative stress and rheumatoid arthritis

P I Mapp, M C Grootveld and D R Blake

Inflammation Research Group, London Hospital Medical College Whitechapel, London

Abstract

The synovial cavity has a negative pressure in health. When the joint is exercised, vascular patency is maintained, allowing for nutrition of the avascular cartilage.

In rheumatoid synovitis, the situation is altered. The cavity pressure is raised and upon movement this pressure exceeds the capillary perfusion pressure, causing collapse of the blood vessels. This leads to the production of multiple episodes of ‘hypoxic-reperfusion injury’ generating reactive oxygen species (ROS). Such ROS oxidise:

  • lgG, inducing rheumatoid factor production
  • Hyaluronan, leading to hyaluronan fragmentation products which may alter immune function
  • Lipids, generating aldehydes which are toxic and may alter T cell/macrophage interactions
  • lipoproteins, leading to the production of monocyte chemotactic peptides

Progressive hypoxia alters immune function, predominantly by calcium mediated pathways.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 The Journal of RheumatologyHome page
M. C. BOSCO, S. DELFINO, F. FERLITO, M. PUPPO, A. GREGORIO, C. GAMBINI, M. GATTORNO, A. MARTINI, and L. VARESIO
The Hypoxic Synovial Environment Regulates Expression of Vascular Endothelial Growth Factor and Osteopontin in Juvenile Idiopathic Arthritis
J Rheumatol, June 1, 2009; 36(6): 1318 - 1329.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Charbonneau, K. Harper, F. Grondin, M. Pelmus, P. P. McDonald, and C. M. Dubois
Hypoxia-inducible Factor Mediates Hypoxic and Tumor Necrosis Factor {alpha}-induced Increases in Tumor Necrosis Factor-{alpha} Converting Enzyme/ADAM17 Expression by Synovial Cells
J. Biol. Chem., November 16, 2007; 282(46): 33714 - 33724.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
D. Manzanares, M.-E. Monzon, R. C. Savani, and M. Salathe
Apical Oxidative Hyaluronan Degradation Stimulates Airway Ciliary Beating via RHAMM and RON
Am. J. Respir. Cell Mol. Biol., August 1, 2007; 37(2): 160 - 168.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Cross, T. Barnes, R. C. Bucknall, S. W. Edwards, and R. J. Moots
Neutrophil apoptosis in rheumatoid arthritis is regulated by local oxygen tensions within joints
J. Leukoc. Biol., September 1, 2006; 80(3): 521 - 528.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
E Simelyte, D L Boyle, and G S Firestein
DNA mismatch repair enzyme expression in synovial tissue
Ann Rheum Dis, December 1, 2004; 63(12): 1695 - 1699.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
L. V. Collins, S. Hajizadeh, E. Holme, I.-M. Jonsson, and A. Tarkowski
Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses
J. Leukoc. Biol., June 1, 2004; 75(6): 995 - 1000.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
J. A. Martin, A. J. Klingelhutz, F. Moussavi-Harami, and J. A. Buckwalter
Effects of Oxidative Damage and Telomerase Activity on Human Articular Cartilage Chondrocyte Senescence
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2004; 59(4): B324 - B336.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
T. Schioppa, B. Uranchimeg, A. Saccani, S. K. Biswas, A. Doni, A. Rapisarda, S. Bernasconi, S. Saccani, M. Nebuloni, L. Vago, et al.
Regulation of the Chemokine Receptor CXCR4 by Hypoxia
J. Exp. Med., November 3, 2003; 198(9): 1391 - 1402.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M.-K. Han, J.-S. Kim, B.-H. Park, J.-R. Kim, B.-Y. Hwang, H.-Y. Lee, E.-K. Song, and W.-H. Yoo
NF-{kappa}B-dependent lymphocyte hyperadhesiveness to synovial fibroblasts by hypoxia and reoxygenation: potential role in rheumatoid arthritis
J. Leukoc. Biol., April 1, 2003; 73(4): 525 - 529.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S.-H. Lee, D. K. Chang, A. Goel, C. R. Boland, W. Bugbee, D. L. Boyle, and G. S. Firestein
Microsatellite Instability and Suppressed DNA Repair Enzyme Expression in Rheumatoid Arthritis
J. Immunol., February 15, 2003; 170(4): 2214 - 2220.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
H. Zhang, L. M. Kamendulis, and J. E. Klaunig
Mechanisms for the Induction of Oxidative Stress in Syrian Hamster Embryo Cells by Acrylonitrile
Toxicol. Sci., June 1, 2002; 67(2): 247 - 255.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
W. Droge
Free Radicals in the Physiological Control of Cell Function
Physiol Rev, January 1, 2002; 82(1): 47 - 95.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
A. J. Pool and J. S. Axford
The effects of exercise on the hormonal and immune systems in rheumatoid arthritis
Rheumatology, June 1, 2001; 40(6): 610 - 614.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
V. M. Corrigall, M. D. Bodman-Smith, M. S. Fife, B. Canas, L. K. Myers, P. H. Wooley, C. Soh, N. A. Staines, D. J. C. Pappin, S. E. Berlo, et al.
The Human Endoplasmic Reticulum Molecular Chaperone BiP Is an Autoantigen for Rheumatoid Arthritis and Prevents the Induction of Experimental Arthritis
J. Immunol., February 1, 2001; 166(3): 1492 - 1498.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
P. A. Varisco, V. Péclat, K. van Ness, A. Bischof-Delaloye, A. So, and N. Busso
Effect of thrombin inhibition on synovial inflammation in antigen induced arthritis
Ann Rheum Dis, October 1, 2000; 59(10): 781 - 787.
[Abstract] [Full Text]

Home page
 Int ImmunolHome page
D. R. Karp, M. L. Carlisle, A. B. Mobley, T. C. Nichols, N. Oppenheimer-Marks, R. I. Brezinschek, and V. M. Holers
{gamma}-Glutamyl transpeptidase is up-regulated on memory T lymphocytes
Int. Immunol., November 1, 1999; 11(11): 1791 - 1800.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Yoshida, T. Katoh, T. Tetsuka, K. Uno, N. Matsui, and T. Okamoto
Involvement of Thioredoxin in Rheumatoid Arthritis: Its Costimulatory Roles in the TNF-{alpha}-Induced Production of IL-6 and IL-8 from Cultured Synovial Fibroblasts
J. Immunol., July 1, 1999; 163(1): 351 - 358.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. O'Donnell, I. C. Harkes, L. Dougherty, and I. P. Wicks
Expression of Receptor Tyrosine Kinase Axl and its Ligand Gas6 in Rheumatoid Arthritis : Evidence for a Novel Endothelial Cell Survival Pathway
Am. J. Pathol., April 1, 1999; 154(4): 1171 - 1180.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. D. Watson, N. Leitinger, M. Navab, K. F. Faull, S. Horkko, J. L. Witztum, W. Palinski, D. Schwenke, R. G. Salomon, W. Sha, et al.
Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence in Vivo
J. Biol. Chem., May 23, 1997; 272(21): 13597 - 13607.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.