British Medical Bulletin 52:453-464 (1996)
© 1996 The British Council
research-article |
The genetics of mental retardation
Institute of Molecular Medicine, John Radcliffe Hospital Oxford, UK
Dr Jonathan Flint, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Abstract
We review the advances that have been achieved using molecular genetic techniques to characterise the genetic basis of mental retardation in recognised syndromes and in discovering new genetic conditions that give rise to mental retardation. However, even with the cloning of a number of mutant genes, the pathogenesis of the condition is not understood. The genetics of mental retardation are turning out to be remarkably complex and are likely to remain a challenge for clinicians and scientists for years to come.
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