Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (35)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Liddle, P. F
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liddle, P. F
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 52:486-494 (1996)
© 1996 The British Council

research-article

Functional imaging — schizophrenia

Peter F Liddle

Department of Psychiatry, University of British Columbia Vancouver, British Columbia, Canada

Abstract

Evidence from recent studies of brain function in schizophrenia confirms that the frontal underactivity reported in earlier studies is a feature only of cases with decreased psychomotor activity, while patients with different symptom profile have different patterns of cerebral activity. Each of the three major groups of schizophrenic symptoms reflects a specific pattern of aberrant cerbral activity in association cortex of frontal, parietal and temporal lobes, and in related subcortical nuclei. These patterns indicate imbalances between neuronal activity at diverse interconnected brain sites, rather than abnormal function at a single location. Furthermore, during the performance of executive tasks, schizophrenic subjects exhibit impaired frontal activation, while during memory tasks there a tendency towards impaired temporal lobe activation. The difficulty activating a particular region does not reflect fixed loss of function. Rather the evidence indicates that the characteristic feature of schizophrenia is disturbed connectivity between cerebral areas.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Arch Gen PsychiatryHome page
D. Hubl, T. Koenig, W. Strik, A. Federspiel, R. Kreis, C. Boesch, S. E. Maier, G. Schroth, K. Lovblad, and T. Dierks
Pathways That Make Voices: White Matter Changes in Auditory Hallucinations
Arch Gen Psychiatry, July 1, 2004; 61(7): 658 - 668.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
K. L. Davis, D. G. Stewart, J. I. Friedman, M. Buchsbaum, P. D. Harvey, P. R. Hof, J. Buxbaum, and V. Haroutunian
White Matter Changes in Schizophrenia: Evidence for Myelin-Related Dysfunction
Arch Gen Psychiatry, May 1, 2003; 60(5): 443 - 456.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
J. D. Ragland, R. C. Gur, J. Raz, L. Schroeder, C. G. Kohler, R. J. Smith, A. Alavi, and R. E. Gur
Effect of Schizophrenia on Frontotemporal Activity During Word Encoding and Recognition: A PET Cerebral Blood Flow Study
Am J Psychiatry, July 1, 2001; 158(7): 1114 - 1125.
[Abstract] [Full Text]

Home page
 Arch Gen PsychiatryHome page
S. Heckers, D. Goff, D. L. Schacter, C. R. Savage, A. J. Fischman, N. M. Alpert, and S. L. Rauch
Functional Imaging of Memory Retrieval in Deficit vs Nondeficit Schizophrenia
Arch Gen Psychiatry, December 1, 1999; 56(12): 1117 - 1123.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
R. E. Hoffman, J. Rapaport, C. M. Mazure, and D. M. Quinlan
Selective Speech Perception Alterations in Schizophrenic Patients Reporting Hallucinated "Voices"
Am J Psychiatry, March 1, 1999; 156(3): 393 - 399.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.