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British Medical Bulletin 52:513-526 (1996)
© 1996 The British Council

research-article

Psychopharmacology — in vivo neurochemistry and pharmacology

Paul Grasby, Andrea Malizia and Chris Bench

MRC Cyclotron Unit, Clinical Sciences Center, Hammersmith Hospital London, UK

Dr Paul Grasby, MRC Cyclatron Unit, Clinical Science Center, Hammersmith Hospital, DuCane Road, London, W12 0HS, UK.

Abstract

Positron emission tomography (PET) and single photon emission computerized tomography (SPECT) brain imaging techniques are powerful tools for the investigation of human neurochemistry and psychopharmacology. These versatile in vivo methods can be used to measure brain receptor populations in psychiatric illness, to determine receptor occupancy and tissue pharmacokinetics of psychotropic drugs and to examine the functional effects of drug-induced neurotransmitter manipulation. This chapter review recent innovative basic and clinical studies, of relevance to psychiatry, and discussed methodological developments that extend the use of these techniques.


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