| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
British Medical Bulletin 52:597-617 (1996)
© 1996 The British Council
research-article |
The neuroendocrinology of depression and chronic stress
Institute of Psychiatry London, UK
Abstract
This chapter will review basic and clinical studies of the social, genetic and developmental influcences upon the reactivity of the hypothalamic pituitary adrenal (HPA) axis and the relationship of these to depression. Significant advances have taken place in each of these areas and it is now possible to interlink many of these areas of work. In order to do so, this chapter will be organised into five sections. The first section will show how the neuroendocrinology of chronic stress is characterised by an up-regulation of the central drive to the HPA axis in conjuntion with down-regulation of its negative feedback control. The second will show that very similar processes occur in depressive illness. The third section will describe social, developmental and genetic influences on the HPA axis both in experimental animals and in man. The fourth will show how activation of the HPA axis can influence the development of animal models of depression as well as the onset and perpetuation of clinical depression. The final section will draw together an overall hypothesis and indicate the potential for new treatments for depression that arise from this work.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. Enthoven, M. S. Oitzl, N. Koning, M. van der Mark, and E. R. de Kloet Hypothalamic-Pituitary-Adrenal Axis Activity of Newborn Mice Rapidly Desensitizes to Repeated Maternal Absence but Becomes Highly Responsive to Novelty Endocrinology, December 1, 2008; 149(12): 6366 - 6377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Wichers, I. Myin-Germeys, N. Jacobs, G. Kenis, C. Derom, R. Vlietinck, P. Delespaul, R. Mengelers, F. Peeters, N. Nicolson, et al. Susceptibility to Depression Expressed as Alterations in Cortisol Day Curve: A Cross-Twin, Cross-Trait Study Psychosom Med, April 1, 2008; 70(3): 314 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Million, L. Wang, M. P. Stenzel-Poore, S. C. Coste, P. Q. Yuan, C. Lamy, J. Rivier, T. Buffington, and Y. Tache Enhanced pelvic responses to stressors in female CRF-overexpressing mice Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1429 - R1438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nierop, A. Bratsikas, R. Zimmermann, and U. Ehlert Are Stress-Induced Cortisol Changes During Pregnancy Associated With Postpartum Depressive Symptoms? Psychosom Med, November 1, 2006; 68(6): 931 - 937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. P I Pembroke, F. Rasul, C. L Hart, G. Davey Smith, and S. A Stansfeld Psychological distress and chronic obstructive pulmonary disease in the Renfrew and Paisley (MIDSPAN) study. J Epidemiol Community Health, September 1, 2006; 60(9): 789 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wust, E. F. C. van Rossum, I. S. Federenko, J. W. Koper, R. Kumsta, and D. H. Hellhammer Common Polymorphisms in the Glucocorticoid Receptor Gene Are Associated with Adrenocortical Responses to Psychosocial Stress J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 565 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pruessner, D. H. Hellhammer, J. C. Pruessner, and S. J. Lupien Self-Reported Depressive Symptoms and Stress Levels in Healthy Young Men: Associations With the Cortisol Response to Awakening Psychosom Med, January 1, 2003; 65(1): 92 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Harrison The neuropathology of primary mood disorder Brain, July 1, 2002; 125(7): 1428 - 1449. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Steptoe and M. Marmot The role of psychobiological pathways in socio-economic inequalities in cardiovascular disease risk Eur. Heart J., January 1, 2002; 23(1): 13 - 25. [Full Text] [PDF]
|
|
|
|
|
|
E. F. Domino History of Modern Psychopharmacology: A Personal View With an Emphasis on Antidepressants Psychosom Med, September 1, 1999; 61(5): 591 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Weninger, A. J. Dunn, L. J. Muglia, P. Dikkes, K. A. Miczek, A. H. Swiergiel, C. W. Berridge, and J. A. Majzoub Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH PNAS, July 6, 1999; 96(14): 8283 - 8288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Gibson, S. Checkley, A. Papadopoulos, L. Poon, S. Daley, and J. Wardle Increased Salivary Cortisol Reliably Induced by a Protein-Rich Midday Meal Psychosom Med, March 1, 1999; 61(2): 214 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. de Kloet, E. Vreugdenhil, M. S. Oitzl, and M. Joëls Brain Corticosteroid Receptor Balance in Health and Disease Endocr. Rev., June 1, 1998; 19(3): 269 - 301. [Abstract] [Full Text]
|
|