Theoretical neurobiology and schizophrenia

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British Medical Bulletin 52:644-655 (1996)
© 1996 The British Council

research-article

Theoretical neurobiology and schizophrenia

Karl J Friston

The Wellcome Department of Cognitive Neurology, Institute of Neurology London, UK

Abstract

This chapter addresses the idea that schizophrenia is a ‘disconnectionsyndrome’ from a therotical and computational perspective.The distinction between anatomical and functional connectivityis reviewed and used as a framework to introduce empirical andcomputational evidence that schizophrenia involves, at somelevel, a disintegration of neuronal interactions. The chapterconcludes with an example of complexity of neuronal dynamicsin schizophrenia to the disconnection hypothesis.

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