Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Pritchard-Jones, K
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pritchard-Jones, K
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 52:704-723 (1996)
© 1996 The British Council

research-article

Genetics of childhood cancer

K Pritchard-Jones

Institute of Cancer Research/Royal Marsden NHS Trust Sutton, Surrey, UK

K Pritchard-Jones, CRC Senior Lecturer in Paediatric Oncology, Institute of Cancer Research/Royal Marsden NHS Trust, Downs Road, Sutton, Surrey SM2 5PT, UK

Abstract

In the last 5 years, there has been a tremendous increase in understanding of the molecular genetics of several childhood cancers. The genes for more than 10 cancer predisposition syndromes are now cloned and the molecular basis of their functioning is being analysed. The classical model of inherited cancer predisposition being due to mutation of tumour suppressor genes is being expanded to include genes involved in DNA processing and weakly dominant oncogenes. The chromosomal translocations characteristic of specific types of sporadic tumours are yielding to the molecular knife, with the isolation of many of the genes disrupted in both leukaemias and solid tumours. Common structural motifs are seen among the proteins which are brought together by translocation to produce novel fusion proteins. Detection of translactions in solid tumours has been made simpler by the introduction of molecular techniques which do not rely on karyotyping.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.