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British Medical Bulletin 52:764-777 (1996)
© 1996 The British Council

research-article

Acute myeloid leukaemia

Richard F Stevens

Royal Manchester Children's Hospital Manchester, UK

Richard F Stevens, Consultant Paediatric Haematologist, Royal Manchester Children's Hospital, Pendlebury, Manchester M27 4HA, UK

Abstract

There has been considerable progress in the understanding and treatment of childhood acute myeloid leukaemia over the past two decades. In particular, cyto-and molecular genetics offer the potential for more specific diagnosis of what is basically a heterogeneous disease. To date treatment has been based on a steady increase in cytotoxic chemotherapy with or without the addition of bone marrow transplantation. Randomised therapeutic trials are difficult to perform in what is a rare disease. The best way forward is for paediatric trial groups worldwide to collaborate in developing common, or parallel, therapeutic protocols.


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