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British Medical Bulletin 52:778-786 (1996)
© 1996 The British Council

research-article

Paediatric myelodysplasia

S J Passmore and I M Hann

Department of Haematology and Oncology, Great Ormond Street Children's Hospital London, UK

I M Hann, Department of Haematology and Oncology, Great Ormond Street Children's Hospital, London WC1N 3JH, UK

Abstract

Myelodysplastic syndromes (MDS) in childhood comprise a heterogeneous group of disorders, many of which respond poorly to intensive chemotherapy; the only curative treatment for these is bone marrow transplant (BMT). There are, however, some types of paediatric MDS with a slower, more indolent course, and it is important to differentiate these and tailor treatment accordingly. The prognosis for children with MDS who have a matched sibling BMT is improving and, as experience of unrelated donor BMT is gained, this treatment modality is likely to become available for the majority of the remainder.


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