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British Medical Bulletin 53:135-155 (1997)
© 1997 The British Council

research-article

The early origins of schizophrenia

Peter Jones

Department of Psychiatry, University of nottingham Nottingham, UK

Dr P B Jones, Department of Psychiatry, University of Nottingham, Duncan Macmillan House, Porchester Road, Nottingham NG3 6AA, UK

Abstract

Large population-based studies indicate that children who will as adults develop the clinical syndrome of schizophrenia are different from their peers in terms of the acquisition of a range of neurological, cognitive and behavioural characteristics. These studies are also identifying possible causal factors which might operate early in life and so be responsible for a longitudinal aspect of the disorder. Studies of the brain yield results consistent with the multi-system nature of the clinical syndrome of schizophrenia in adult life, and with the notion of a longitudinal or deveolpmental phenotype, of which the adult syndrome is but one aspect. Work in these areas is reviewed with special reference to national birth cohorts from Britain and Finland.


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