| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
British Medical Bulletin 53:58-70 (1997)
© 1997 The British Council
research-article |
The beginnings of chronic airflow obstruction
Department of Public Health Medicine, St Thomas's Hospital London, UK
Dr S O Shaheen, Department of Public Health Medicine, St Thomas's Hospital, Lambeth Palace Road, London SEI 7EH, UK
Abstract
Recent follow-up studies have provided convincing evidence that the foundations of chronic airflow obstruction (CAO)are laid in utero and early childhood. Men born in Hertfordshire and Derbyshire, England, were more likely to have impaired lung function at 60–70 years of age if they had been lighter at birth and if they had had lower respiratory tract infection (LRTI) in the first 2 year of life. Furthermore, they were more likely to have died from chronic obstructive pulmonary disease if they had been lighter at 1 year of age. These findings suggest that impairment of pulmonary growth in utero and early childhood, as a consequence of undernutrition and LRTI, plays an important part in the development of CAO in late adult life. This may be of particular importance for the future respiratory health of developing nations as the additive effects of smoking take hold.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. F. Suglia, R. O. Wright, J. Schwartz, and R. J. Wright Association Between Lung Function and Cognition Among Children in a Prospective Birth Cohort Study Psychosom Med, April 1, 2008; 70(3): 356 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Suglia, L. Ryan, F. Laden, D. W. Dockery, and R. J. Wright Violence Exposure, A Chronic Psychosocial Stressor, and Childhood Lung Function Psychosom Med, February 1, 2008; 70(2): 160 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ganguly, T. Stoeger, S. C. Wesselkamper, C. Reinhard, M. A. Sartor, M. Medvedovic, C. R. Tomlinson, I. Bolle, J. M. Mason, G. D. Leikauf, et al. Candidate genes controlling pulmonary function in mice: transcript profiling and predicted protein structure Physiol Genomics, November 14, 2007; 31(3): 410 - 421. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. I. Rennard Chronic Obstructive Pulmonary Disease: Linking Outcomes and Pathobiology of Disease Modification Proceedings of the ATS, May 1, 2006; 3(3): 276 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Metcalfe, G. Davey Smith, J. A. C. Sterne, P. Heslop, J. Macleod, and C. L. Hart Cause-specific hospital admission and mortality among working men: association with socioeconomic circumstances in childhood and adult life, and the mediating role of daily stress Eur J Public Health, June 1, 2005; 15(3): 238 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Naess, B. Claussen, D. S Thelle, and G. Davey Smith Cumulative deprivation and cause specific mortality. A census based study of life course influences over three decades J. Epidemiol. Community Health, July 1, 2004; 58(7): 599 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F W Lipfert and S C Morris Temporal and spatial relations between age specific mortality and ambient air quality in the United States: regression results for counties, 1960-97 Occup. Environ. Med., March 1, 2002; 59(3): 156 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. I. Harik-Khan, J. L. Fleg, and R. A. Wise Body Mass Index and the Risk of COPD Chest, February 1, 2002; 121(2): 370 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Tager Air Pollution and Lung Function Growth . Is It Ozone? Am. J. Respir. Crit. Care Med., August 1, 1999; 160(2): 387 - 389. [Full Text]
|
|
|
|
 |
|
 S. O Shaheen, J. A C Sterne, S. M Montgomery, and H. Azima Birth weight, body mass index and asthma in young adults Thorax, May 1, 1999; 54(5): 396 - 402. [Abstract] [Full Text]
|
|