British Medical Bulletin 53:286-306 (1997)
© 1997 The British Council
research-article |
Neurobiology
Diabetes and Endocrinology Research Group, University of Liverpool Liverpool, UK
Correspondence to: Dr John Wilding, Diabetes and Endocrinology Research Group, University of Liverpool, Liverpool, L69 3BX UK
Abstract
The role of neuropeptide Y(NPY), leptin and 5-HT and other neurotransmitters implicated in the regulation of energy balance are only now being fully investigated. Little is known about how they may interact with each other in this complex process. In evolutionary terms, the availbility of excess food, and the risk of obesity, is only a recent occurrence is humans. Man, and perhaps other species, may not have developed a specialised neurochemical system for adjustimg food intake during obesity. Hence perturbation of a single system, such as hypothalamic NPY or leptin, is unlikely to be directly responsible fot the development of most obesity. In contrast, periods of food deprivation and partial starvation have been common in the animal kingdom and the multitude of neurotransmitters implicated in energy balance are more likely to be directed towards increasing food consumption and conserving energy than reducing appetite and increasing thermogenesis in the presence of excess
The last few years have witnessed rapid advances in the understanding of the fundamental mechanisms that regulate body weight and fat content. This progress will undoubtedly continue in the future, and it is hoped that this will be rewarded with the development of new drugs to treat obesity. At present, however, it is unclear whether NPY, leptin, or other apparently strong candidates will be the winner in the lucrative race for the ideal anti-obestiy drug.
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  J. Wilding Science, medicine, and the future: Obesity treatment BMJ, October 18, 1997; 315(7114): 997 - 1000. [Full Text]
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