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British Medical Bulletin 53:409-432 (1997)
© 1997 The British Council

research-article

Present and future pharmacological approaches

Nick Finer

Centre for Obesity Research, London and Dunstable Hospital Luton, UK

correspondence to: Dr Nick Finer, Centre for Obesity Research, The Luton and Dunstable NHS Trust, Lewsey Road, Luton, Bedfordshire LU4 ODZ, UK

Abstract

There is evidence that drugs altering food intake such as dexfenfluramine, sibutramine and orlistat have useful therapeutic effects, with an acceptable side effect profile. ‘Thermogenic’ drugs, such as ephedrine and caffeine, are also effective, but less well tolerated and may, in any case, work by producing anorexia. The state of drug treatment for obesity now is similar to the early days of anti-hypertensive treatment in the 1960s when reserpine, ganglion blockers and non-selective adrenergic blocker were all that was available. There is considerable reason for optimism that the next 10 years will bring better treatments for the obese.


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