British Medical Bulletin 54:151-162 (1998)
© 1998 The British Council
research-article |
Carcinogenesis, apoptosis and cell proliferation
Departments of Pathology and Pediatrics, Louisiana State University Medical Center and Stanley S. Scott Cancer Center New Orleans, Louisiana, USA
Correspondence to: Prof Pelayo Correa, Departments of Pathology and Pediatrics, Louisiana State University Medical Center and Stanley S. Scott Cancer Center, 1901 Perdido Street, Box P5-1, New Orleans, LA 70112-1393, USA.
Abstract
Biological agents, especially viruses, have been linked to the carcinogenesis process in major human cancers, especially lymphomas (retroviruses), hepatocarcinomas (hepatitis viruses) and carcinomas of the female genital organs (papilloma viruses). Chronic infection and inflammation have long been suspected to play a role in human carcingoenesis. Helicobacter pylori is the first bacterial infection reconized as a human carcinogen, essentially on the basis of epidemiological evidence of causality1. Contrary to most other recognized human carcinogens, experimental evidence of carcinogenesis is lacking. As a consequence, mechanistic explanations of H. pylori carcinogenesis at this point in time are hypothetical.
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