| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
British Medical Bulletin 54:207-216 (1998)
© 1998 The British Council
research-article |
Antibiotic resistance in Helicobacter pylori infection
Laboratoire de Bactériologie, Hôpital Pellegrin Bordeaux, France
Correspondence to: Prof. Francis Mégraud, Laboratoire de Bactériologie, Hôpital Pellegrin, 33076 Bordeaux Cedex, France
Abstract
Resistance to antibiotic is considered as the primary reason for failure of eradication therapies. Resistance to clarithromycin is due to a decrease in binding to the ribosomes associated with a point mutation on the 23S rRNA. Its rate in Europe varies from 0–15%. with 5% in the UK. The resistance influences dramatically the success of the treatments. Resistance to metronidazole is due to a lack of reduction of this compound whose genetic basic is still unknown, The resistance rate in Europe varies from 10–50%, with 25% in the UK. It influences the success of treatments to a lesser extent than clarithromycin resistance.
The initial eradication treatment can be prescribed without testing for susceptibility and must include a combination of two antibiotics, while stressing the importance of compliance to the patient. In case of failure, susceptibility testing must be performed.
Few data are currently available on alternative therapeutic strategies when H. pylori is resistant to both clarithromycin and metronidazole.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Lottspeich, A. Schwarzer, K. Panthel, S. Koletzko, and H. Russmann Evaluation of the Novel Helicobacter pylori ClariRes Real-Time PCR Assay for Detection and Clarithromycin Susceptibility Testing of H. pylori in Stool Specimens from Symptomatic Children J. Clin. Microbiol., June 1, 2007; 45(6): 1718 - 1722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. Kwon, M. P. Dore, J. J. Kim, M. Kato, M. Lee, J. Y. Wu, and D. Y. Graham High-Level {beta}-Lactam Resistance Associated with Acquired Multidrug Resistance in Helicobacter pylori Antimicrob. Agents Chemother., July 1, 2003; 47(7): 2169 - 2178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Okamoto, H. Yoshiyama, T. Nakazawa, I.-D. Park, M.-W. Chang, H. Yanai, K. Okita, and M. Shirai A change in PBP1 is involved in amoxicillin resistance of clinical isolates of Helicobacter pylori J. Antimicrob. Chemother., December 1, 2002; 50(6): 849 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. BOYANOVA, R. KOUMANOVA, G. GERGOVA, M. POPOVA, I. MITOV, Y. KOVACHEVA, S. DEREJIAN, N. KATSAROV, R. NIKOLOV, and Z. KRASTEV Prevalence of resistant Helicobacter pylori isolates in Bulgarian children J. Med. Microbiol., September 1, 2002; 51(9): 786 - 790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Russmann, K. Adler, R. Haas, B. Gebert, S. Koletzko, and J. Heesemann Rapid and Accurate Determination of Genotypic Clarithromycin Resistance in Cultured Helicobacter pylori by Fluorescent In Situ Hybridization J. Clin. Microbiol., November 1, 2001; 39(11): 4142 - 4144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P Sutton, S J Danon, M Walker, L J Thompson, J Wilson, T Kosaka, and A Lee Post-immunisation gastritis and Helicobacter infection in the mouse: a long term study Gut, October 1, 2001; 49(4): 467 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Osato, R. Reddy, S. G. Reddy, R. L. Penland, H. M. Malaty, and D. Y. Graham Pattern of Primary Resistance of Helicobacter pylori to Metronidazole or Clarithromycin in the United States Arch Intern Med, May 14, 2001; 161(9): 1217 - 1220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M E Street, P Caruana, C Caffarelli, W Magliani, M Manfredi, F Fornaroli, and G L de'Angelis Antibiotic resistance and antibiotic sensitivity based treatment in Helicobacter pylori infection: advantages and outcome Arch. Dis. Child., May 1, 2001; 84(5): 419 - 422. [Abstract] [Full Text]
|
|
|
|
|
|
H. Rüssmann, V. A. J. Kempf, S. Koletzko, J. Heesemann, and I. B. Autenrieth Comparison of Fluorescent In Situ Hybridization and Conventional Culturing for Detection of Helicobacter pylori in Gastric Biopsy Specimens J. Clin. Microbiol., January 1, 2001; 39(1): 304 - 308. [Abstract] [Full Text]
|
|
|
|
|
|
D.-H. Kwon, F. A. K. El-Zaatari, M. Kato, M. S. Osato, R. Reddy, Y. Yamaoka, and D. Y. Graham Analysis of rdxA and Involvement of Additional Genes Encoding NAD(P)H Flavin Oxidoreductase (FrxA) and Ferredoxin-Like Protein (FdxB) in Metronidazole Resistance of Helicobacter pylori Antimicrob. Agents Chemother., August 1, 2000; 44(8): 2133 - 2142. [Abstract] [Full Text]
|
|
|
|
|
|
K Trebesius, K Panthel, S Strobel, K Vogt, G Faller, T Kirchner, M Kist, J Heesemann, and R Haas Rapid and specific detection of Helicobacter pylori macrolide resistance in gastric tissue by fluorescent in situ hybridisation Gut, May 1, 2000; 46(5): 608 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. BOYANOVA, I. STANCHEVA, Z. SPASSOVA, N. KATZAROV, I. MITOV, and R. KOUMANOVA Primary and combined resistance to four antimicrobial agents in Helicobacter pylori in Sofia, Bulgaria J. Med. Microbiol., May 1, 2000; 49(5): 415 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Blaser In a World of Black and White, Helicobacter pylori Is Gray Ann Intern Med, April 20, 1999; 130(8): 695 - 697. [Full Text] [PDF]
|
|
|
|
|
|
R J OWEN Helicobacter pylori resists arrest Gut, April 1, 1999; 44(4): 447 - 448. [Full Text] [PDF]
|
|