Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (13)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Butterworth, A E
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Butterworth, A E
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 54:357-368 (1998)
© 1998 The British Council

research-article

Immunological aspects of human schistosomiasis

A E Butterworth

Formerly Medical Research Council External Scientific Staff and Honorary Professor in Medical Parasitology, University of Cambridge Cambridge, UK

Correspondence to Dr A E Butterworth 47 The Footpath, Coton, Cambridge CB3 7PX UK

Abstract

Helminth infections are characteristically associated with Th2-dependent responses leading to lgE production and eosinophilia. However, the effect of such responses varies between different hosts. In murine schistosomiasis, for example, Th1 responses are associated with protection against infection, and Th2 responses with egg-induced morbidity. In human schistosomiasis, in contrast, Th2 responses with the production of lgE antibodies against a restricted range of adult worm antigens are associated with protection against reinfection after chemotherapy, while individuals in whom Th2 responses against egg antigens predominate show less severe egg-associated morbidity than those in whom Th1 responses predominate. It is suggested that Th2-mediated responses are selectively advantageous to the human host in the context of schistosomiasis and possibly other helminth infections. The implications of this for vaccination, for control through chemotherapy, and for the study of interactions with other infections are briefly discussed.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
C. Carvalho-Queiroz, R. Cook, C. C. Wang, R. Correa-Oliveira, N. A. Bailey, N. K. Egilmez, E. Mathiowitz, and P. T. LoVerde
Cross-Reactivity of Schistosoma mansoni Cytosolic Superoxide Dismutase, a Protective Vaccine Candidate, with Host Superoxide Dismutase and Identification of Parasite-Specific B Epitopes
Infect. Immun., May 1, 2004; 72(5): 2635 - 2647.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
A. G. P. Ross, A. C. Sleigh, Y. Li, G. M. Davis, G. M. Williams, Z. Jiang, Z. Feng, and D. P. McManus
Schistosomiasis in the People's Republic of China: Prospects and Challenges for the 21st Century
Clin. Microbiol. Rev., April 1, 2001; 14(2): 270 - 295.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.