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British Medical Bulletin 55:309-324 (1999)
© 1999 The British Council

research-article

New technologies and DNA resources for high throughtput biology

Nigel Spurr, Ariel Darvasi, Jonathan Terrett and Liz Jazwinska

Biotechnology and Genetics SmithKline Beecham, Harlow, Essex, UK

Correspondence to: Dr Nigel Spurr, Biotechnology and Genetics, Smithkline Beecham, New Frontiers Science Park (North), Third Avenue, Harlow, Essex CM19 5AW, UK

Abstract

The rapid increase in DNA sequencing information is opening up new opportunities in genetics. The current methods for processing and analysing genetic data are, however, slow and labour intensive. The next wave of genetic analysis will rely on the analysis of DNA variation from large population based cohorts. These studies will provide important new data on population and disease genetics and have the potential to make a significant impact on our current healthcare practices. In order for thses studies to deliver, we need to develop a new generation of ultra-rapid DNA technologies which will allow us to generate, capture and efficiently exploit these new data. This chapter describes the recent advances in DNA sequencing and genotyping technologies that will lead to 100–1000-fold increases in our ability to produce the DNA data we need to explore and exploit the new genetic opportunities to the full.


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