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British Medical Bulletin 55:387-400 (1999)
© 1999 The British Council

research-article

Pathogen virulence genes – implications for vaccines and drug therapy

Christoph Tang* and David Holden{dagger},

*Department of Paediatrics, John Radcliffe Hospital Oxford, UK,
{dagger}Department of Infectious Diseases, Imperial College of Science, Technology and Medicine, Hammersmith Hospital London, UK

Correspondence to: Prof. David Holden, Department of Infectious Diseases, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK

Abstract

The emergence and spread of bacteria resistant to antimicrobial drugs is a major public health problem with a growing number of infections becoming virtually untreatable. There is a need to develop interventions both to prevent and to treat diseases caused by multi-resistant microbes. We review some recently developed methods (including whole genome uncleotide sequencing projects) to study bacterial pathogenesis, and discuss how knowledge gained from understanding the molecular mechanisms of disease can be applied to combat the threat of infectious diseases.


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