Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (22)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Cox, D. W
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cox, D. W
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 55:544-555 (1999)
© 1999 The British Council

research-article

Disorders of copper transport

Diane W Cox

Department of Medical Genetics, University of Alberta Edmonton, Alberta, Canada

Prof. Diane W Cox, Department of Medical Genetics, 8–39 Medical Sciences Building, University of Alberta, Edmonton, Alberta T6G 2H7, Canada

Abstract

Copper is an essential component of a number of important enzymes. Efficient systems have developed for providing sufficient copper for essential functions, while eliminating excess to avoid tissue toxicity. Copper transport is disrupted in two human diseases: Wilson disease and Menkes disease. Both have defects in copper transporting membrane proteins. Many other proteins are involved in copper transport. Some of these proteins have been identified through a study of the similar copper pathway in yeast. This suggests other copper transport diseases are yet to be discovered. Molecular diagnosis holds promise for reliable diagnosis of patients. Testing of flanking markers is a reliable way to detect presymptomatic sibs of a definite patient.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
N. R. Zerounian, C. Redekosky, R. Malpe, and M. C. Linder
Regulation of copper absorption by copper availability in the Caco-2 cell intestinal model
Am J Physiol Gastrointest Liver Physiol, May 1, 2003; 284(5): G739 - G747.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
I.D. de Wolf, A.C.M. Bonne, X.M. Fielmich-Bouman, B.A. van Oost, A.C. Beynen, L.F.M. van Zutphen, and H.A. van Lith
Quantitative Trait Loci Influencing Hepatic Copper in Rats
Experimental Biology and Medicine, July 1, 2002; 227(7): 529 - 534.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
B. Zhang, D. Egli, O. Georgiev, and W. Schaffner
The Drosophila Homolog of Mammalian Zinc Finger Factor MTF-1 Activates Transcription in Response to Heavy Metals
Mol. Cell. Biol., July 15, 2001; 21(14): 4505 - 4514.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. C. Andrews
Mining copper transport genes
PNAS, June 5, 2001; 98(12): 6543 - 6545.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Landriscina, C. Bagala, A. Mandinova, R. Soldi, I. Micucci, S. Bellum, I. Prudovsky, and T. Maciag
Copper Induces the Assembly of a Multiprotein Aggregate Implicated in the Release of Fibroblast Growth Factor 1 in Response to Stress
J. Biol. Chem., June 29, 2001; 276(27): 25549 - 25557.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.