Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (21)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Arthur, J. R
Right arrow Articles by Beckett, G. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arthur, J. R
Right arrow Articles by Beckett, G. J
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 55:658-668 (1999)
© 1999 The British Council

research-article

Thyroid function

John R Arthur*, and Geoffrey J Beckett{dagger}

*Division of Micronutrient and Lipid Metabolism, Rowett Research Institute Aberdeen, UK
{dagger}University of Department of Clinical Biochemistry, The Royal Infirmary Edinburgh, UK

Correspondence to: Dr J R Arthur, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK

Abstract

Normal thyroid status is dependent on the presence of many trace elements for both the synthesis and metabolism of thyroid hormones. Iodine is most important as a component of the hormones, thyroxine and 3,3',5-tri-iodothyronine (T3) and iodine deficiency may affect approximately one billion people throughout the world. Selenium is essential for normal thyroid hormone metabolism being involved with selenium-containing iodothyronine de-iodinases that control the synthesis and degradation of the biologically active thyroid hormone, T3. Additionally, selenoperoxidases and thioredoxin reductase protect the thyroid gland from peroxides produced during the synthesis of hormones. The roles of iron, zinc and copper in the thyroid are less well defined but sub- or supra-optimal dietary intakes of all these elements can adversely affect thyroid hormone metabolism.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. Sato, M. Iemitsu, K. Aizawa, and R. Ajisaka
Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle
Am J Physiol Endocrinol Metab, May 1, 2008; 294(5): E961 - E968.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. P Rayman, A. J Thompson, B. Bekaert, J. Catterick, R. Galassini, E. Hall, M. Warren-Perry, and G. J Beckett
Randomized controlled trial of the effect of selenium supplementation on thyroid function in the elderly in the United Kingdom
Am. J. Clinical Nutrition, February 1, 2008; 87(2): 370 - 378.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. Schomburg, C. Riese, M. Michaelis, E. Griebert, M. O. Klein, R. Sapin, U. Schweizer, and J. Kohrle
Synthesis and Metabolism of Thyroid Hormones Is Preferentially Maintained in Selenium-Deficient Transgenic Mice
Endocrinology, March 1, 2006; 147(3): 1306 - 1313.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.