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British Medical Bulletin 56:616-629 (2000)
© 2000 The British Council

research-article

Male infertility and intracytoplasmic sperm injection (ICSI)

Alastair J Campbell and D Stewart Irvine

MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology Edinburgh, UK

Correspondence to Dr D Stewart Irvine, MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers St, Edinburgh EH3 9ET, UK

Abstract

Micro-assisted fertilization in the form of intracytoplasmic sperm injection (ICSI) has truly revolutionised the treatment options for couples with impaired semen quality, and those with both obstructive and non-obstructive azoospermia. In general, the major issues which relate to the success of ICSI are those related to the success of conventional IVF, and the high multiple pregnancy rate remains a major cause for concern. There is growing evidence that the shor-term health of ICSI offspring is relatively unremarkable, but our growing understanding of the genetic basis of much of male subfertility and of the impaired genomic integrity which characterises the oligozoospermic phenotype indicate a cautious approach to the longer term health of ICSI offspring.


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