Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (33)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Fraser, H. M
Right arrow Articles by Lunn, S. F
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fraser, H. M
Right arrow Articles by Lunn, S. F
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 56:787-797 (2000)
© 2000 The British Council

research-article

Angiogenesis and its control in the female reproductive system

Hamish M Fraser and Stephen F Lunn

MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology Edinburgh, UK

Correspondence to Dr Hamish M Fraser, MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK

Abstract

The rapid, controlled and cyclical nature of angiogenesis in the female reporductive tract suggests that interference with this process should provide a novel approach to manipulation of reproductive function. Many factors involved in the regulation of angiogenesis have been identified, and the possibility of stimulating or inhibiting these paracrine control mechanisms is being addressed using current advances in the development of angiogenic and anti-angiogenic compounds. Studies with animal models indicate that the normal processes of folliculogenesis, ovulation and corpus luteum function in the ovary, and the control of menstruation and implantation in the endometrium could be profoundly influenced by manipulation of angiogenesis. Novel therapeutic agents targeted to the angiogenic pathway may also have a wide range of applications in pathological processes in the reproductive tract such as cancer, endometriosis, fibroid growth, and ovarian hyperstimulation syndrome.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
N. L. Ward, E. Moore, K. Noon, N. Spassil, E. Keenan, T. L. Ivanco, and J. C. LaManna
Cerebral angiogenic factors, angiogenesis, and physiological response to chronic hypoxia differ among four commonly used mouse strains
J Appl Physiol, May 1, 2007; 102(5): 1927 - 1935.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. M. Fraser, H. Wilson, K. D. Morris, I. Swanston, and S. J. Wiegand
Vascular Endothelial Growth Factor Trap Suppresses Ovarian Function at All Stages of the Luteal Phase in the Macaque
J. Clin. Endocrinol. Metab., October 1, 2005; 90(10): 5811 - 5818.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. Greenaway, P. A. Gentry, J.-J. Feige, J. LaMarre, and J. J. Petrik
Thrombospondin and Vascular Endothelial Growth Factor Are Cyclically Expressed in an Inverse Pattern During Bovine Ovarian Follicle Development
Biol Reprod, May 1, 2005; 72(5): 1071 - 1078.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. S. Nakhuda, R. C. Zimmermann, P. Bohlen, F. Liao, M. V. Sauer, and J. Kitajewski
Inhibition of the Vascular Endothelial Cell (VE)-Specific Adhesion Molecule VE-Cadherin Blocks Gonadotropin-Dependent Folliculogenesis and Corpus Luteum Formation and Angiogenesis
Endocrinology, March 1, 2005; 146(3): 1053 - 1059.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. M. Bastida, A. Cremades, M. T. Castells, A. J. Lopez-Contreras, C. Lopez-Garcia, F. Tejada, and R. Penafiel
Influence of Ovarian Ornithine Decarboxylase in Folliculogenesis and Luteinization
Endocrinology, February 1, 2005; 146(2): 666 - 674.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
A. Hoeben, B. Landuyt, M. S. Highley, H. Wildiers, A. T. Van Oosterom, and E. A. De Bruijn
Vascular Endothelial Growth Factor and Angiogenesis
Pharmacol. Rev., December 1, 2004; 56(4): 549 - 580.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
N. Ferrara
Vascular Endothelial Growth Factor: Basic Science and Clinical Progress
Endocr. Rev., August 1, 2004; 25(4): 581 - 611.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J.B. Laoag-Fernandez, T. Maruo, P. Pakarinen, I.M. Spitz, and E. Johansson
Effects of levonorgestrel-releasing intra-uterine system on the expression of vascular endothelial growth factor and adrenomedullin in the endometrium in adenomyosis
Hum. Reprod., April 1, 2003; 18(4): 694 - 699.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S.F. Lunn, H.M. Fraser, and H.D. Mason
Structure of the corpus luteum in the ovulatory polycystic ovary
Hum. Reprod., January 1, 2002; 17(1): 111 - 117.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Wulff, H. Wilson, J. S. Rudge, S. J. Wiegand, S. F. Lunn, and H. M. Fraser
Luteal Angiogenesis: Prevention and Intervention by Treatment with Vascular Endothelial Growth Factor TrapA40
J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3377 - 3386.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.