Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (17)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Feijen, M.
Right arrow Articles by Postma, D. S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Feijen, M.
Right arrow Articles by Postma, D. S
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 56:894-907 (2000)
© 2000 The British Council

research-article

Genetics of allergic disease

Marlies Feijen*,{dagger}, Jorrit Gerritsen{dagger} and Dirkje S Postma{ddagger},

*Department of Pulmonary Rehabilitation, Beatrixoord Rehabilitation Centre Haren, The Netherlands
{dagger}Department of Pediatric Pulmonology, Beatrix Children's Clinic The Netherlands
{ddagger}Department of Pulmonology, University Hospital Groningen The Netherlands

Correspondence to:Prof. Dr Dirkje S Postma, Department of Pulmonology, University Hospital Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands

Abstract

Atopy can express itself as asthma, rhinitis and eczema. The presence of atopy can be assessed by increased levels of total serum IgE and specific IgE to common allergens, skin test positivity and increased numbers of peripheral blood eosinophils. Genetic studies indicate that multiple genes are involved in the pathogenesis of atopy and that different genes regulate the presence of increased levels of serum total IgE and specific IgE. Linkage of these traits to chromosomal regions likely to contain atopic susceptibility genes has been replicated in several studies. Genome-wide screens have identified several new chromosomal locations that are likely to contain atopic genes. These regions also contain candidate genes. Moreover, the available literature suggests that multiple, yet different genes may be involved in the translation of atopy to a distinct clinical phenotype. We anticipate that understanding of the genetic basic of atopy will lead to new therapeutic interventions and early diagnosis.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
A. R. O'Donnell, B. G. Toelle, G. B. Marks, C. M. Hayden, I. A. Laing, J. K. Peat, J. Goldblatt, and P. N. Le Souef
Age-specific Relationship between CD14 and Atopy in a Cohort Assessed from Age 8 to 25 Years
Am. J. Respir. Crit. Care Med., March 1, 2004; 169(5): 615 - 622.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
B. Granum and M. Lovik
The Effect of Particles on Allergic Immune Responses
Toxicol. Sci., January 1, 2002; 65(1): 7 - 17.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.