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British Medical Bulletin 58:187-203 (2001)
© 2001 Oxford University Press

Immune interventions

The changing face of HIV and AIDS

John Wilkinson and Frances Gotch

Department of Immunology, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London, UK

A better understanding of the immune response to HIV and the deleterious effect that HIV infection may have on the immune system in general, allows us to consider how best to restore protective immune responses to HIV and other opportunistic pathogens in the immunocompromised host. In this chapter, we summarise areas of current innovation and provide an update of the current state of knowledge concerning interventions which could result in the immunocompromised state being reversed. We describe the kinds of immune responses, which are thought to be useful in combating both the human immunodeficiency virus and other pathogenic organisms, and methods which are being considered to stimulate such responses. Lessons which may be learned from other disease states, which lead to immunodeficiency and methods for measuring successful outcome of treatment will be described.


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