Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (39)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Clapham, P. R
Right arrow Articles by McKnight, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Clapham, P. R
Right arrow Articles by McKnight, A.
Related Collections
Right arrow HIV/AIDS
Right arrow Immunology
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 58:43-59 (2001)
© 2001 The British Council

HIV-1 receptors and cell tropism

Paul R Clapham* and Áine McKnight{dagger}

* Center for AIDS Research, Program in Molecular Medicine, Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
{dagger} The Wohl Virion Center, Department of Immunology and Molecular Pathology, The Windeyer Institute for Medical Sciences, University College, London, UK

HIV virus particles interact with several receptors on cell surfaces. Two receptors, CD4 and a co-receptor act sequentially to trigger fusion of viral and cellular membranes and confer virus entry into cells. For HIV-1, the chemokine receptor CCR5 is the predominant co-receptor exploited for transmission and replication in vivo. Variants that switch to use CXCR4 and perhaps other co-receptors evolve in some infected individuals and have altered tropism and pathogenic properties. Other cell surface receptors including mannose binding protein on macrophages and DC-SIGN on dendritic cells also interact with gp120 on virus particles but do not actively promote fusion and virus entry. These receptors may tether virus particles to cells enabling interactions with suboptimal concentrations of CD4 and/or co-receptors. Alternatively such receptors may transport cell surface trapped virions into lymph nodes before transmitting them to susceptible cells. Therapeutic strategies that prevent HIV from interacting with receptors are currently being developed. This review describes how the interaction and use of different cellular receptors influences HIV tropism and pathogenesis in vivo.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Virol.Home page
C. M. Chan, S. K. P. Lau, P. C. Y. Woo, H. Tse, B.-J. Zheng, L. Chen, J.-D. Huang, and K.-Y. Yuen
Identification of Major Histocompatibility Complex Class I C Molecule as an Attachment Factor That Facilitates Coronavirus HKU1 Spike-Mediated Infection
J. Virol., January 15, 2009; 83(2): 1026 - 1035.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
S. Thibault, M. R. Tardif, C. Gilbert, and M. J. Tremblay
Virus-associated host CD62L increases attachment of human immunodeficiency virus type 1 to endothelial cells and enhances trans infection of CD4+ T lymphocytes
J. Gen. Virol., September 1, 2007; 88(9): 2568 - 2573.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. Gilbert, R. Cantin, C. Barat, and M. J. Tremblay
Human Immunodeficiency Virus Type 1 Replication in Dendritic Cell-T-Cell Cocultures Is Increased upon Incorporation of Host LFA-1 due to Higher Levels of Virus Production in Immature Dendritic Cells
J. Virol., July 15, 2007; 81(14): 7672 - 7682.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
A. Bugatti, C. Urbinati, C. Ravelli, E. De Clercq, S. Liekens, and M. Rusnati
Heparin-Mimicking Sulfonic Acid Polymers as Multitarget Inhibitors of Human Immunodeficiency Virus Type 1 Tat and gp120 Proteins
Antimicrob. Agents Chemother., July 1, 2007; 51(7): 2337 - 2345.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Gilbert, C. Barat, R. Cantin, and M. J. Tremblay
Involvement of Src and Syk Tyrosine Kinases in HIV-1 Transfer from Dendritic Cells to CD4+ T Lymphocytes
J. Immunol., March 1, 2007; 178(5): 2862 - 2871.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. R. Dewin, J. Catusse, and U. A. Gompels
Identification and Characterization of U83A Viral Chemokine, a Broad and Potent {beta}-Chemokine Agonist for Human CCRs with Unique Selectivity and Inhibition by Spliced Isoform
J. Immunol., January 1, 2006; 176(1): 544 - 556.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. Zaitseva, T. Romantseva, J. Manischewitz, J. Wang, D. Goucher, and H. Golding
Increased CXCR4-dependent HIV-1 fusion in activated T cells: role of CD4/CXCR4 association
J. Leukoc. Biol., December 1, 2005; 78(6): 1306 - 1317.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Manel, J.-L. Battini, and M. Sitbon
Human T Cell Leukemia Virus Envelope Binding and Virus Entry Are Mediated by Distinct Domains of the Glucose Transporter GLUT1
J. Biol. Chem., August 12, 2005; 280(32): 29025 - 29029.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. E. Jeeninga, B. Jan, B. van der Linden, H. van den Berg, and B. Berkhout
Construction of a Minimal HIV-1 Variant that Selectively Replicates in Leukemic Derived T-Cell Lines: Towards a New Virotherapy Approach
Cancer Res., April 15, 2005; 65(8): 3347 - 3355.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. A. Jeffers, S. M. Tusell, L. Gillim-Ross, E. M. Hemmila, J. E. Achenbach, G. J. Babcock, W. D. Thomas Jr., L. B. Thackray, M. D. Young, R. J. Mason, et al.
CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus
PNAS, November 2, 2004; 101(44): 15748 - 15753.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. V. Su, P. Hong, S. Baik, O. A. Negrete, K. B. Gurney, and B. Lee
DC-SIGN Binds to HIV-1 Glycoprotein 120 in a Distinct but Overlapping Fashion Compared with ICAM-2 and ICAM-3
J. Biol. Chem., April 30, 2004; 279(18): 19122 - 19132.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. Schmitz, D. Marchant, S. J. D. Neil, K. Aubin, S. Reuter, M. T. Dittmar, and A. McKnight
Lv2, a Novel Postentry Restriction, Is Mediated by both Capsid and Envelope
J. Virol., February 15, 2004; 78(4): 2006 - 2016.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. M. Goodenow, S. L. Rose, D. L. Tuttle, and J. W. Sleasman
HIV-1 fitness and macrophages
J. Leukoc. Biol., November 1, 2003; 74(5): 657 - 666.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. Melchjorsen, L. N. Sorensen, and S. R. Paludan
Expression and function of chemokines during viral infections: from molecular mechanisms to in vivo function
J. Leukoc. Biol., September 1, 2003; 74(3): 331 - 343.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
K. S. Jones, M. Nath, C. Petrow-Sadowski, A. C. Baines, M. Dambach, Y. Huang, and F. W. Ruscetti
Similar Regulation of Cell Surface Human T-Cell Leukemia Virus Type 1 (HTLV-1) Surface Binding Proteins in Cells Highly and Poorly Transduced by HTLV-1-Pseudotyped Virions
J. Virol., November 13, 2002; 76(24): 12723 - 12734.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
C. L. Fuller, Y. K. Choi, B. A. Fallert, S. Capuano III, P. Rajakumar, M. Murphey-Corb, and T. A. Reinhart
Restricted SIV Replication in Rhesus Macaque Lung Tissues During the Acute Phase of Infection
Am. J. Pathol., September 1, 2002; 161(3): 969 - 978.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.