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British Medical Bulletin 61:45-61 (2002)
© 2002 Oxford University Press

Macrophage defences against respiratory tract infections

The immunology of childhood respiratory infections

S B Gordon*,,{dagger} and R C Read{dagger}

* Wellcome Trust Research Laboratories, Universities of Malawi and Liverpool (UK), Queen Elizabeth Central Hospital, Blantyre, Malawi
{dagger} Division of Genomic Medicine, University of Sheffield Medical School, Royal Hallamshire Hospital, Sheffield, UK

Pulmonary macrophages with a key role in defence against respiratory infection are a heterogeneous family of cells with phagocytic, antigen processing and immunomodulatory functions. Macrophages are important in both innate and acquired immunity in the respiratory tract, and have a role in lung defence against viruses, bacteria, mycobacteria and fungi. Interactions of pathogens with lung macrophages is strongly influenced by soluble immune components including complement, collectins and immunoglobulins. Macrophage function can be modulated by cytokines, environmental exposures, recent and chronic infection including HIV infection, drug therapy and gene transfer.


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