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British Medical Bulletin 62:125-138 (2002)
© 2002 The British Council

Vaccines against persistent DNA virus infections

M R Wills, A J Carmichael and J G P Sissons

Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK

Persistent viruses present some particular problems for vaccine design. As for acute non-persistent viruses, the prime goal of a vaccine should be to prevent primary infection. Vaccines might also be used to modify the course of established persistent virus infections – so-called postinfective immunisation. This chapter deals with selected persistent DNA viruses, in particular the human herpes viruses.


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